MEIS1 down-regulation by MYC mediates prostate cancer development through elevated HOXB13 expression and AR activity

HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling.

Androgen receptor (AR) signals play a decisive role in regulating the growth and differentiation of both normal and cancerous prostate cells by triggering the regulation of target genes, in a process in which AR cofactors have critical functions. Because of the highly prostate-specific expression pattern of HOXB13, we studied the role of this homeodomain protein in prostate cells. Expression of...

Epigallocatechin-3-Gallate Induces Apoptosis through Up-regulation of Bax and Down-regulation of Bcl-2 in Prostate Cancer Cell Line

Background and Aims: Epigallocatechin-3-gallate (EGCG) is a polyphenolic compound from green tea, which its anticancer effects on many types of cancers have been confirmed, but the molecular mechanism by which EGCG induces apoptosis remains unknown. The aim of the present study was to investigate anti-proliferative properties and apoptotic signaling pathway of EGCG on PC3 human prostate cancer ...

Geraniol suppresses prostate cancer growth through down‐regulation of E2F8

Geraniol, an acyclic dietary monoterpene, has been found to suppress cancer survival and growth. However, the molecular mechanism underlying the antitumor action of geraniol has not been investigated at the genome-wide level. In this study, we analyzed the microarray data obtained from geraniol-treated prostate cancer cells. Geraniol potently altered a gene expression profile and primarily down...

Down Regulation of DHFR Promoter Activity by PML Transcription Repressor

HOXB13 mutations and prostate cancer in Poland

Recently, HOXB13 has been established as a prostate cancer susceptibility gene in North America, with a relative risk associated with a single missense mutation of about 20. Ewing et al., sequenced over 200 genes in a prostate cancer linkage region at 17q21-22 among 94 probands of prostate cancer families, and found a recurrent mutation in the HOXB13 gene (G84E) in four families. The mutation c...